Description
IGF1R inhibitor
Scientific Background: Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP (1). Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM (1). Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 uM (2). Exhibits antiangiogenic activitiy (3). Attenuates intimal hyperplasia after vascular injury (4). Active in vivo